New Indole Alkaloids from the Bark of Rauvolfia Reflexa and their Cholinesterase Inhibitory Activity.įadaeinasab, Mehran Basiri, Alireza Kia, Yalda Karimian, Hamed Ali, Hapipah Mohd Murugaiyah, Vikneswaran However, more detailed researches are still required as in vivo testing its anticholinesterase and antioxidant activities. Thus, it is suggested that Snakin-Z may be beneficial in the treatment of AD.

The Snakin-Z also had the high antioxidant activity (IC50 = 0.75 Â± 0.09 mg/mL). This peptide has 80% enzyme inhibitory activity on AChE and BChE at 1.5 mg/mL. The half maximal inhibitory concentration (IC50) values of Snakin-Z against AChE and BChE are 0.58 Â± 0.08 and 0.72 Â± 0.085 mg/mL, respectively. The Snakin-Z displayed considerable cholinesterase inhibition against AChE and BChE. This peptide was introduced as a new peptide and named Snakin-Z. In this study, a new peptide from Ziziphus jujuba fruits was investigated for its inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase ( BChE) enzymes as well as antioxidant activity. Zare-Zardini, Hadi Tolueinia, Behnaz Hashemi, Azam Ebrahimi, Leila Fesahat, FarzanehĪntioxidant agents and cholinesterase inhibitors are the foremost drugs for the treatment of Alzheimer's disease (AD). Antioxidant and cholinesterase inhibitory activity of a new peptide from Ziziphus jujuba fruits.

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